Algorithms And Data Structures

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By Avcibas, Memon, Sankur, Sayood

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In addition to setting an ‘upper boundary’ to monitor the trial for conclusive evidence of treatment benefit, the DMC implemented a ‘lower boundary’ to monitor for conclusive evidence of treatment harm. 025 probability of falsely concluding harm for a treatment truly having no effect on survival. In the CAST publication of primary trial results, this lower boundary was referred to as the advisory boundary for harm. As the Specific tasks 25 CAST trial evolved, this boundary for harm was crossed very quickly, despite the prior expectation for treatment benefit.

These data provided evidence of a striking threefold difference in HIV infection rates in the infants. 3%) were culture positive. 0001, with this strength of evidence clearly meeting the prespecified O’Brien–Fleming statistical guideline. Because AZT was provided to infants until 6 weeks of age, the DMC required evidence that the drug was actually reducing the risk of HIV infection, rather than simply masking the infection in viral cultures obtained during the infant’s first 24 weeks of life. The evidence that no additional cases of positive viral cultures were discovered in the 70 infants followed between 24 and 72 weeks was important in the DMC’s deliberation about the convincingness of trial results.

In this capacity, the DMC may also make recommendations about modifications in study design or conduct, or in procedures for data management, quality control or reporting, as will be discussed later in this chapter. In turn, the study investigators and sponsor, who retain the ultimate responsibility for the design, conduct and reporting of the trial, should promptly review such recommendations and decide on the course of action they judge to be in the best interest of the study and its patients.

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A Progressive Lossless Near-Lossless Image Compression Algorithm by Avcibas, Memon, Sankur, Sayood


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