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Download PDF by Alan Peters, Deborah W. Vaughan (auth.), John E. Johnson Jr.: Aging and Cell Structure: Volume 1

By Alan Peters, Deborah W. Vaughan (auth.), John E. Johnson Jr. (eds.)

ISBN-10: 1468439294

ISBN-13: 9781468439298

ISBN-10: 1468439316

ISBN-13: 9781468439311

Approaching any job on getting older brings a flood of pictures which are a private repetition of what has been one of many maximum and so much continual matters of mankind. Even limiting time to the previous decade or so and drawing close purely the biomedical sciences, one nonetheless encounters a flood of data during this really younger study quarter. The­ ories and concepts abound as if every one researcher presents one among his personal. this may good be anticipated; getting older is an incredibly complex sequence of crossroads concerning trails or even superhighways. every one professional has a peephole (society, physique, organ, tissue, mobile, or-especially in smooth biology-cellular organelles, macromolecules, or even molecules) and the perspectives of the crossroads are patently diverse. for that reason, the num­ ber of observations near to equals the variety of self reliant rules recommend. it's usual to hunt from hugely really expert wisdom a primary comprehend­ ing of getting older during the glossy examine traits in biology that concentrate on occasions on the mobile, subcellular, macromolecular, and molecular degrees. the last word clues needs to lie there-with one severe problem: there are various phone kinds in any physique and every phone sort is a really advanced desktop of its personal. also, there are strength repercussions in that varied cells, tissues, or even molecules affect each other. this can be certainly a complicated scenario, and one for which we needs to search trustworthy solutions, only if we will take a step again and supply a generalized view.

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Peterson. 12. CHOROID PLEXUS The choroid plexus is primarily responsible for the formation of the cerebrospinal fluid, which is contained within the ventricles and which can pass between the ependymal cells lining these cavities to contribute to the extracellular fluid bathing the cellular components of the neuropil. In a recent study, transmission and scanning electron microscopy were used to examine the choroid plexus in the lateral ventricles of aging rats (Peters and Swan, 1979), and it was shown that although there is some increase in the lysosomes and other inclusions within the choroidal cells with age, this increase is not very great.

1979, Loss ofaxosomatic synapses in the dentate gyrus of aged rats, Brain Res. 168:485492. , 1976, Decrease in the number of synapses in the senescent brain: A quantitative electron microscopic analysis of the dentate gyrus molecular layer in the rat, Mech. Ageing Dev. 5:11-23. , and Dodge, J. , 1977, Partial deafferentation of neurons in the dentate gyrus of the senescent rat, Brain Res. 134:541-545. , and Scheibel, A. , 1967, Synaptic loci on visual cortical neurons of the rabbit: The specific afferent radiation, Exp.

The RER is minimal in 15-month-old animals, and thereafter increases to occupy a maximal volume fraction in older rats. On the other hand, the relative volume occupied by other cytoplasmic organelles such as multivesicular bodies, mitochondria, and the Golgi apparatus remains essentially constant throughout life (Fig. 11). A similar decrease in the cytoplasmic space occupied by ground substance has been found by Hinds and McNelly (1979) in the mitral cells of the olfactory bulb. However, in these neurons the volume fraction occupied by the RER remains constant, although in terms of the changes within individual cells the total volume of RER increases until 27 months of age, because the volumes of the mitral cells are also increasing during this period of time.

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Aging and Cell Structure: Volume 1 by Alan Peters, Deborah W. Vaughan (auth.), John E. Johnson Jr. (eds.)

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